It is my opinion that two processes create the symptoms that we see present; both mitochondrial cytopathy and cellular senescence. Both of these pathogenic processes overlap and are interrelated.
These pathogenic processes cause the vast array of symptoms that we see and encompass skeletal muscles and tendons, and dysfunctions in the nervous, visual renal, digestive and circulatory systems. In a sense every body system can be impacted.
Undergirding these symptomatic processes is the driver of FQ induced defects in the respiratory chain inside the mitochondrion. This assembly line of protein complexes is the heart of the mitochondria and a malfunctioning chain can cause a dizzying array of symptoms. I have postulated a theory called Mitochondrial Retrograde Signaling in FQAD, A Disease Theory. This theory explains the chronic cases.
Some of you will understand what I just wrote and others will just go “huh?” Seriously, I could write for pages and pages but believe me the FQ’s have the ability to insert themselves into almost every body system. That is what makes them such potent antibiotics and such a nightmarish ‘hell’ when things go awry.
researchers need to discuss pain more, where in the body it’s most common, and emphasize if anyone feels the smallest inflammation, or anything wrong, they must STOP taking the pills. Explain why it can build up slowly and give patient a false sense of security, as if it’s going to go away when you stop. NO. It is a silent killer, It can slowly build up in the system and then explode. after 10 days of floxin, suddenly i woke up with both calves and achilles tendons so sore I could not walk. and it’s been 24 years and i’m in chronic intractible pain. for my whole destroyed life. If there is no statute of limitations on murder, the law needs to change for drug reactions too. They are permanent. Our biology and chemistry is permanently damaged. billions of cells have been murdered by Johnson and Johnson, the first and biggest liars by pushing this drug on doctors and making billions with no system of reparations for us ‘war victims’ . that’s how it feels. that’s how it is.