Fluoroquinolone Document Library
The following files are available for download or reading as a help to the fluoroquinolone victim community .
Disclaimer: This site may contain copyrighted material, the use of which has not always been specifically authorized by the copyright owner(s). Such material is made available for educational purposes, under the ‘fair use’ provision as provided for in Title 17 U.S.C. section 107 of the US Copyright Law.
Publication: Research Hypothesis
Based on the large amount of anecdotal data collected over several years, combined with recent clinical diagnostics from a few cases of FQAD, this paper suggests a novel hypothesis.
Publication: Hand Out
This is a Fact Sheet or Quick Guide to Fluoroquinolone Antibiotic Toxicity. It can be freely distributed and printed out as a quick reference and advocacy tool.
Academic Paper
Dr. Charles Bennett Suicide Paper for the European Journal of Medicine July 20 2018 produced with help from the FQ community.
FDA Document
FDA JOINT MEETING OF THE ANTIMICROBIAL DRUGS ADVISORY COMMITTEE AND THE DRUG SAFETY AND RISK MANAGEMENT ADVISORY COMMITTEE Transcript 11/05/2015
FDA Document
FDA requires label changes to warn of risk for possibly permanent nerve damage from antibacterial fluoroquinolone drugs taken by mouth or by injection issued 08/15/2013
FDA Document
FDA Briefing Document Joint Meeting of the Antimicrobial Drugs Advisory Committee and the Drug Safety and Risk Management Advisory Committee November 5, 2015 where the FDA coined “FQAD”
Academic Paper
Drug Features That Contribute to the Activity of Quinolones against Mammalian Topoisomerase II and Cultured Cells: Correlation between Enhancement of Enzyme-Mediated DNA Cleavage In Vitro and Cytotoxic Potential October 1993
Article
Adverse Reactions to Fluoroquinolones, written by James Roberts M.D. 2008 Emergency Medicine Newsletter
Academic Paper
The Effect of Bacerial DNA Gyrase Inhibitors on DNA Synthesis In Mammalian Mitochondria. This paper documents that Naladixic Acid (grandfather of today’s FQ’s) damages mitochondrial DNA. 1983
Citizen Petition
Citizen Petition – Add a Black Box Warning to the Levaquin Label Regarding “Possible Mitochondrial Toxicity” by Dr. Bennett to FDA June 2014
Citizen Petition
Citizen Petition – Levaquin Label Change to Add Psychiatric Adverse Events Sept 2014
Academic Paper
Genotoxic and cytotoxic effects of antibacterial drug, ciprofloxacin, on human lymphocytes in vitro. India 2008.
Dear Doctor Letter
This is a “Dear Colleague” letter written by Dr. Miriam J. de Jonge M.D. who herself was damaged by fluoroquinolones. I am posting this letter as a service to the FQ community at her request.
“Dear Doctor” Letter
This is a “Dear Doctor” letter written by Dr. Todd Plumb M.D. who himself was damaged by fluoroquinolones. This is provided as an information download to the fluoroquinolone community.
FDA Document
Response from FDA to Dr. Charles Bennett Dated July 10th, 2018 Detailing Psychiatric Changes to FQ Labels.
FDA Document
Obtained by FOIA FDA Peripheral Neuropathy Internal Memo from 2013 considered by some to be a “smoking gun” in terms of the FDA acknowledging PN as being induced by mitochondrial damage.
Academic Paper
Paper that shows the fluoroquinolones have a strong effect in decreasing mtDNA-encoded proteins in eukaryotic cells 2010.
Community Created Paper
The FLOX Report Rev. 12: Considered by some FQ victims as the best informational document written on FQ damage. It is being provided here as an assistance to the fluoroquinolone victim community. Caution is advised, content can be too intense for some readers.
Community Created Paper
The FLOX Report Rev. 11: Considered by some FQ victims as the best informational document written on FQ damage. It is being provided here as an assistance to the fluoroquinolone victim community. Caution is advised, content can be too intense for some readers.
Academic Paper
Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study 2018
Academic Paper
Fluoroquinolone Utilization in the Emergency Departments of Academic Medical Centers. Prevalence of and risk factors for Inappropriate use. 10/28/2015
Academic Paper
Fluoroquinolone-related neuropsychiatric and mitochondrial toxicity: a collaborative investigation by scientists and members of a social network Published by Dr Bennett Feb 2016
Academic Paper
Case Study. Fluoroquinolone-induced serious, persistent, multisymptom adverse effects. A BMJ case study by Dr. Beartrice Golomb UCSD
FDA Document
Department of Health and Human Services Public Health Service Food and Drug Administration Center for Drug Evaluation and Research Office of Surveillance and Epidemiology Pediatric Postmarketing Pharmacovigilance and Drug Utilization Review 04/27/2012
Academic Paper
Metal Complexes of Quinolone Antibiotics and Their Applications: An Update Valentina Uivarosi 2013
Clinical Review
Musculoskeletal Complications of Fluoroquinolones: Guidelines and Precautions for Usage in the Athletic Population Mederic M. Hall, MD, Jonathan T. Finnoff, DO, Jay Smith, MD Mayo 2011
Academic Paper
The Article “Peripheral Neuropathy Associated with Fluoroquinolones” written by Jay S Cohen M.D. and published in the Annals of Pharmacotherapy in December 2001.
Academic Paper
Non-antibiotic effects of fluoroquinolones in mammalian cells. This important July 2015 Mayo paper documents that “FQ antibiotics induce global epigenetic changes”
Academic Paper
Nonclassical Biological Activities of Quinolone Derivatives 2012
Citizen Petition
Dr Bennett & Sonar Citizen Petition Black Box Warning FQAD June 2019
Article
Not Your Mother’s Mitochondrial Disease: Myths & Facts About Mitochondrial Cytopathies By Sumit Parikh, M.D. & Bruce H. Cohen, M.D. Cleveland Clinic 2006
Academic Paper
Possible involvement of DEC1 on the adverse effects of quinolone antibiotics. China 2010
Academic Paper
Quinolone binding to DNA is mediated by magnesium ions. Italy June 12, 1992
Document
Antibiotics Currently in Clinical Development As of March 2016,
Document
Comprehensive Quinolone List Courtesy of My Quin Story: Life After Levaquin
Document
Reparing the Damaged Plasma Membrane of the Cell and Membrane Bound Organelles 2014
Academic Paper
Fluoroquinolone-associated joint pain in patients with tuberculosis. This paper shows delayed onset of FQ pathology.
Academic Paper
Risk of gastrointestinal perforation in patients taking oral fluoroquinolone therapy: An analysis of nationally representative cohort. China 2017.
Academic Paper
The purpose of this viewpoint is to describe the unfortunate consequences that can occur in a portion of patients taking systemic fluoroquinolones, and to share the view that eye-care practitioners should consider them cytotoxic and potential anti-cancer treatments. Australia May, 2020
Academic Paper
The aim of this study was to evaluate the practice pattern of off-label use of fluoroquinolones (FQs) in ambulatory settings and to identify the related risk factors. United States, 2016
Do you know an important fluoroquinolone related document that belongs here? Send me the link or Contact me and let me know. Thanks.
Denotes papers that I co-authored, assisted in publication, or provided fluoroquinolone related data to the author.
